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Moreover, muscle damage, shown by increased creatine kinase levels in the blood (a systemic measure of myofibre leakiness and damage), is significantly increased in humans with dysferlinopathy (~ 20–200 fold) [2], and in BLA/J mice aged 6, 9, and 12 months (~ 3–5 fold) [15]

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[DOI] [PubMed] [Google Scholar] 103.Muriel P